abstract：:The age-related changes and the acute effects of intravenous melatonin on the activity of striatal neurons of 1-, 3-, 6-, 12-, and 18-month-old sham-operated and pinealectomized rats were investigated. There was a decline in responsiveness from 3- to 18-months of age, although in sham-pinealectomized rats the response...

journal_title：Journal of pineal research

authors： Castillo-Romero JL,Acuña-Castroviejo D,Escamaes G,Vives F

更新日期：1995-09-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) exerts its toxic effects by the generation of free radicals. In this study we investigated whether melatonin, a potent free radical scavenger, could prevent the deleterious effects of CCl4. Liver homogenates and liver microsomes were incubated with CCl4 in the presence of melatonin and lipi...

journal_title：Journal of pineal research

authors： Daniels WM,Reiter RJ,Melchiorri D,Sewerynek E,Pablos MI,Ortiz GG

更新日期：1995-08-01 00:00:00

abstract：:We have studied the postnatal evolution of the glial cells in the rat pineal gland after its chemical pre- and perinatal denervation, by the assessment of the immunocytochemical expression of three antigens characteristic of glial cells i.e., vimentin (VIM), glial fibrillary acidic protein (GFAP), and S-100 protein. T...

journal_title：Journal of pineal research

authors： López-Muñoz F,Boya J

更新日期：1995-05-01 00:00:00

abstract：:As for many hormones, melatonin levels in the blood suggest that it is discharged from the pineal gland in a pulsatile manner. Recently, the existence of short-term episodes, superimposed on the circadian pattern of circulating melatonin, has been questioned. Because plasma melatonin levels reflect not only the secret...

journal_title：Journal of pineal research

authors： Follenius M,Weibel L,Brandenberger G

更新日期：1995-04-01 00:00:00

abstract：:The ultrastructure of the pineal gland in the adult cat is described and compared with that of other mammals. Connective tissue spaces showed capillaries with nonfenestrated endothelia and numerous unmyelinated nerve fibers. In the proximal region of the gland, myelinated nerve fibers coming from the anterior commissu...

journal_title：Journal of pineal research

authors： Boya J,Calvo JL,Rancaño D

更新日期：1995-03-01 00:00:00

abstract：:The aim of this study was to determine, in the rat, the interaction between melatonin and cholecystokinin in the regulation of the ileal interdigestive motility. This was analyzed by the chronic electromyography technique. Ileal motility was defined by the presence of intermittent spike bursts corresponding to the con...

journal_title：Journal of pineal research

authors： Bonouali-Pellissier S

更新日期：1994-09-01 00:00:00

abstract：:The distribution of nerve fibers immunoreactive (IR) to catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (D beta H), and phenylethanolamine-N-methyltransferase (PNMT) as well as neuropeptide Y (NPY), in the pineal gland of adult sows was investigated by the use of double-labelin...

journal_title：Journal of pineal research

authors： Kaleczyc J,Przybylska B,Majewski M,Lewczuk B

更新日期：1994-08-01 00:00:00

abstract：:Studies on farm animals have contributed significantly to our increased understanding of basic melatonin-related physiological mechanisms, as well as to the regulation of reproduction and pelage in individual domestic species. This review concentrates on recent work on the role of melatonin in the regulation of porcin...

journal_title：Journal of pineal research

authors： Paterson AM,Foldes A

更新日期：1994-05-01 00:00:00

abstract：:The effects of melatonin (3 mg/kg i.p.) and the melatonin receptor agonist S-20098 (3 mg/kg i.p.) on the vigilance states, electroencephalogram power spectra (0.25-25.0 Hz), and cortical temperature were determined in eight rats in the first 6-hr interval of the 12-hr light period. Compared to the vehicle injection bo...

journal_title：Journal of pineal research

authors： Tobler I,Jaggi K,Borbély AA

更新日期：1994-01-01 00:00:00

abstract：:Five adult pasture-bred Prim Holstein cows were used to document the time invariance of melatonin disposition in the cow. Melatonin was administered by an intravenous route as a bolus (5 micrograms/kg of body weight) at either 1430 or 2230. Data were analysed according to a three-compartment open model with melatonin ...

journal_title：Journal of pineal research

authors： Berthelot X,Ravault JP,Concordet D,Ferney J,Toutain PL

更新日期：1993-10-01 00:00:00

abstract：:Early studies on the physiological effects of melatonin typically reported hypnotic 'side-effects'. Later studies, specifically addressing this action, failed to reliably replicate hypnotic effects using standard polysomnography. This difference may be related to differences in the basic physiological action of melato...

journal_title：Journal of pineal research

authors： Dawson D,Encel N

更新日期：1993-08-01 00:00:00

abstract：:Melatonin is a very potent and efficient endogenous radical scavenger. The pineal indolamine reacts with the highly toxic hydroxyl radical and provides on-site protection against oxidative damage to biomolecules within every cellular compartment. Melatonin acts as a primary non-enzymatic antioxidative defense against ...

journal_title：Journal of pineal research

authors： Poeggeler B,Reiter RJ,Tan DX,Chen LD,Manchester LC

更新日期：1993-05-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter/neuromodulator involved in cell-to-cell communication within the central nervous system, is now believed to play a role in neuroendocrine function. In this study we describe a single, saturable, stereospecific, and temperature-, time-, and pH-dependent binding site for glutama...

journal_title：Journal of pineal research

authors： Kus L,Handa RJ,McNulty JA

更新日期：1993-01-01 00:00:00

abstract：:Entraining effect of melatonin on the circadian rhythm in rat pineal N-acetyltransferase (NAT) activity was studied under various photoperiods. Melatonin administration prior to dark onset for 5 successive days phase-advanced the evening NAT rise under the light:dark (LD) cycle of either LD 10:14 or LD 8:16, but not u...

journal_title：Journal of pineal research

authors： Humlová M,Illnerová H

更新日期：1992-11-01 00:00:00

abstract：:A study was carried out to determine the possible influence of melatonin on the proliferation of Kirkman-Robbins hepatoma cells in Syrian hamsters, both in vivo and in vitro. A highly significant inhibition of the proliferation of transplanted hepatoma cells was observed in vivo following melatonin administration (pro...

journal_title：Journal of pineal research

authors： Karasek M,Liberski P,Kunert-Radek J,Bartkowiak J

更新日期：1992-10-01 00:00:00

abstract：:Female rats exposed to long (LD 18:6) or short (LD 6:18) photoperiods from 21 days of age were mated when they reached 55 days of age. On day 2 of gestation animals of each group were either pinealectomized or sham-operated. Lighting regimens were not changed during the course of the study. Male offspring of the four ...

journal_title：Journal of pineal research

authors： Jarrige JF,Boucher D

更新日期：1992-09-01 00:00:00

abstract：:Our objective was to suppress the daily surge of melatonin in serum of prepubertal dairy heifers by manipulating intensity of light (Experiment 1) and duration of exposure to light (Experiment 2). Heifers in Experiment 1 were exposed to either 12 hr of darkness (000 lux, control), or 400, 800, or 1,200 lux of light du...

journal_title：Journal of pineal research

authors： Buchanan BA,Chapin LT,Tucker HA

更新日期：1992-05-01 00:00:00

abstract：:Diurnal variations in serum melatonin levels and pineal concentrations of serotonin (5-HT), N-acetylserotonin (NAS), 5-hydroxyindole acetic acid (5-HIAA), and melatonin were estimated in adult male Djungarian hamsters kept under long-day (LD 16:8) or short-day (LD 8:16) photoperiods. The nocturnal increase in melatoni...

journal_title：Journal of pineal research

authors： Lerchl A,Schlatt S

更新日期：1992-04-01 00:00:00

abstract：:Exposure of rats to light during darkness or blockade of the pineal beta-adrenoceptor in stimulated pineal glands results in a rapid fall in pineal N-acetyltransferase (NAT) activity. Maintenance of a high level of NAT activity requires continuous stimulation of the pineal beta-adrenoceptors. It is not known what fact...

journal_title：Journal of pineal research

authors： Olivieri G,Daya S

更新日期：1992-03-01 00:00:00

abstract：:The permeability of the pineal gland to lanthanum was investigated by means of transmission electron microscopy and X-ray microanalysis. Different pineal cell populations were studied. Light pinealocytes as well as glial cells were not permeated by the tracer lanthanum, which normally stays extracellularly. Dark pinea...

journal_title：Journal of pineal research

authors： Humbert W,Pévet P

更新日期：1992-03-01 00:00:00

abstract：:The effect of daily injection of the pineal hormone melatonin and naltrexone, an opioid antagonist, on the circadian rhythm and the level of immune parameters (plaque forming cell [PFC] number, serum agglutinin titer, lymphoid gland weight, total white blood cells (WBC) and their fraction number, and serum lysozyme [L...

journal_title：Journal of pineal research

authors： Skwarło-Sońta K,Thaela MJ,Midura M,Lech B,Głuchowska B,Drela N,Kozłowska E,Kowalczyk R

更新日期：1992-01-01 00:00:00

abstract：:The Syrian hamster pineal displays age-dependent changes in melatonin output measured in vitro. Between the ages of 4 and 19 days, pineal melatonin generation in response to 10 microM norepinephrine (NE) increased 34-fold. Production of melatonin by cultured pineals from 1-week-old hamsters showed a clear dose respons...

journal_title：Journal of pineal research

authors： Kaufman CM,Menaker M

更新日期：1991-10-01 00:00:00

abstract：:The effect of melatonin on thrombin-induced [3H]-arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyze...

journal_title：Journal of pineal research

authors： Martinuzzo M,Del Zar MM,Cardinali DP,Carreras LO,Vacas MI

更新日期：1991-10-01 00:00:00

abstract：:Day and nighttime melatonin production in the pineal gland was compared in normal and cardiomyopathic (polydystrophic) adult male Syrian hamsters. These strains of hamsters were selected for comparison because the cardiomyopathetic hamster displays a deficient transmembrane Ca(2+)-pump in a number of tissues, and intr...

journal_title：Journal of pineal research

authors： Reiter RJ,White T,Lerchl A,Stokkan KA,Rodriguez C

更新日期：1991-10-01 00:00:00

abstract：:A role of D2-dopaminergic neurotransmission in the regulation of melatonin biosynthesis in retina was studied in vivo in chickens. The nighttime rise in serotonin N-acetyltransferase (NAT)--the penultimate and key regulatory melatonin-synthesizing enzyme--was potently inhibited by both acute light exposure and agonist...

journal_title：Journal of pineal research

authors： Zawilska JB,Kazula A,Zurawska E,Nowak JZ

更新日期：1991-10-01 00:00:00

abstract：:The European hedgehog (Erinaceus europaeus L.) is a hibernating mammal and seasonal breeder in which numerous circadian and circannual rhythms are entrained and synchronized by photoperiod. The present study was undertaken in order to establish the involvement of the pineal gland in transducing the photoperiodic messa...

journal_title：Journal of pineal research

authors： Saboureau M,Vivien-Roels B,Pevet P

更新日期：1991-09-01 00:00:00

abstract：:During the past decade, a number of reports indicated that the mammalian pineal gland is magnetosensitive in terms of spatial orientation. This indication is based on observations that artificial alterations of the direction of the earth's magnetic field (MF) markedly decreased the gland's capability to synthesize mel...

journal_title：Journal of pineal research

authors： Lerchl A,Nonaka KO,Reiter RJ

更新日期：1991-04-01 00:00:00

abstract：:The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Bec...

journal_title：Journal of pineal research

authors： Brown GM,Bar-Or A,Grossi D,Kashur S,Johannson E,Yie SM

更新日期：1991-04-01 00:00:00

abstract：:Melatonin has been shown to have a direct inhibitory action on the proliferation of estrogen-responsive MCF-7 human breast cancer cells in culture. In the present study, we examined by flow cytometry whether this inhibitory effect might be exerted on the G1 phase of the cell cycle, thus causing a transition delay into...

journal_title：Journal of pineal research

authors： Cos S,Blask DE,Lemus-Wilson A,Hill AB

更新日期：1991-01-01 00:00:00

abstract：:Previously it has been found that pinealectomy in rats was associated with increased small bowel crypt cell proliferation. The hypothalamus is thought to play a role in the neural control of crypt cell proliferation and the pineal gland is known to be functionally connected with this component of the autonomic nervous...

journal_title：Journal of pineal research

authors： Callaghan BD

更新日期：1991-01-01 00:00:00

abstract：:The frequency of mitoses of adrenaline (A) cells and noradrenaline (N) cells in the adrenal medulla of nonoperated (NO), sham-operated (SPX), and pinealectomized (PX) male, 53-day-old Holtzman rats (n = 133) was investigated by means of light microscopy. Animals were killed at eight time points during a standardized 2...

journal_title：Journal of pineal research

authors： Kachi T,Quay WB,Banerji TK,Imagawa T

更新日期：1990-01-01 00:00:00

abstract：:This study examined plasma melatonin levels and the suppressant effect of light on melatonin production in the squirrel monkey. Monkeys were maintained on a 12:12 light-dark cycle (LD 12:12) with lights on from 07:00 to 19:00. Plasma levels of melatonin were determined by gas chromatography negative chemical ionizatio...

journal_title：Journal of pineal research

authors： Hoban TM,Lewy AJ,Fuller CA

更新日期：1990-01-01 00:00:00

abstract：:The role played by postsynaptic alpha-adrenergic receptors in the stimulation of pineal melatonin production was investigated in the Syrian hamster. The studies were conducted using organ cultured pineal glands collected from both anatomically intact and superior cervical ganglionectomized hamsters. Results obtained i...

journal_title：Journal of pineal research

authors： Santana C,Guerrero JM,Reiter RJ,Menendez-Pelaez A

更新日期：1989-01-01 00:00:00

abstract：:The influence of the pineal gland on the histopathologic changes induced in mammary glands by 7, 12-dimethylbenz(a)-anthracene (DMBA) has been studied. To achieve the maximum expression of pineal action in animals, 28-day-old female Sprague-Dawley rats were subjected to one of the following treatments: blindness + olf...

journal_title：Journal of pineal research

authors： Cos S,Garijo F,Corral J,Mediavilla MD,Sánchez-Barceló EJ

更新日期：1989-01-01 00:00:00

abstract：:Light and electron microscopic demonstrations for acid phosphatase (AcPase) activity in the chicken pineal gland were studied with special reference to the changes induced by the light-dark cycle. AcPase-positive lysosomes and Golgi cisternae and vesicles located in the pinealocyte in the light period are well develop...

journal_title：Journal of pineal research

authors： Ohshima K,Matsuo S

更新日期：1989-01-01 00:00:00

abstract：:We studied the role of nocturnal illuminance as a possible regulatory factor in the production and secretion of reproductive hormones. Adult male rats were kept under artificial lighting conditions (LD 12/12 hours) where the daily illuminance was 520-550 lx and the nocturnal illuminance 0, less than 0.1, or 1-1.5 lx. ...

journal_title：Journal of pineal research

authors： Laakso ML,Porkka-Heiskanen T,Alila A,Kajander S,Stenberg D,Johansson G

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to determine and compare the effects of chronic melatonin treatment in vivo on several aspects of prolactin (PRL) cell activity (PRL synthesis, storage, and release) in vitro in male and female Syrian hamsters. Adult male and female hamsters were maintained on long photoperiod and treated...

journal_title：Journal of pineal research

authors： Blask DE

更新日期：1989-01-01 00:00:00

abstract：:Previous human studies have indicated that daytime melatonin levels increase when the organism is subjected to the stress of fasting and exercise. Melatonin, epinephrine, and norepinephrine levels were measured during a mock run and in the course of treadmill exercise performed before (T-1), during (T-2), and followin...

journal_title：Journal of pineal research

authors： Skrinar GS,Bullen BA,Reppert SM,Peachey SE,Turnbull BA,McArthur JW

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to investigate the localization in the superior cervical ganglia (SCG) of neuropeptide Y-containing neurons innervating the pineal gland. Following injection of the fluorescent tracer Fluoro-Gold (FG) into the superficial part of the pineal gland and retrograde axonal transport, labeled cells...

journal_title：Journal of pineal research

authors： Reuss S,Moore RY

更新日期：1989-01-01 00:00:00

abstract：:Experiments were conducted to determine whether daily melatonin injections could influence reentrainment of circadian locomotor activity rhythms in male Long-Evans rats after phase shifts of the light dark (LD) cycle. When exposed to a 5-h advance of the LD cycle, six out of 15 rats injected daily with melatonin at th...

journal_title：Journal of pineal research

authors： Redman JR,Armstrong SM

更新日期：1988-01-01 00:00:00